1.6 - Mood (Affective) Disorders: Treatment & Management
Introduction to mood disorders and their treatment
Mood disorders, also known as affective disorders, involve persistent disturbances in emotional state, such as prolonged sadness or extreme mood swings. These can significantly impact daily functioning, relationships, and overall wellbeing. Treatment aims to alleviate symptoms and restore balance, often combining biological and psychological methods. Biological approaches target brain chemistry, while psychological ones focus on thought patterns and behaviours.
Biological treatments for mood disorders
Biological treatments primarily involve antidepressant drugs, which work by altering levels of neurotransmitters in the brain. Neurotransmitters are chemical messengers that transmit signals between nerve cells, influencing mood and emotion. These drugs aim to correct imbalances often associated with mood disorders like depression.
Types of antidepressant drugs
Antidepressants come in several classes, each with a specific mode of action and potential side effects.
| Type of antidepressant | Mode of action | Side effects |
|---|---|---|
| Tricyclics | These drugs block the reabsorption of serotonin and noradrenaline by presynaptic transporter molecules, leading to higher levels of these neurotransmitters remaining in the synapse (the gap between nerve cells) to enhance mood regulation. | Dry mouth, dizziness, drowsiness, blurred vision |
| Monoamine oxidase inhibitors (MAOIs) | They prevent the breakdown of serotonin, noradrenaline, and dopamine by inhibiting an enzyme called monoamine oxidase, thereby increasing the availability of these neurotransmitters for longer periods. | Dangerous interactions with tyramine-containing foods (aged cheese, wine) causing hypertensive crisis (severe blood pressure increase); drowsiness, dizziness, nausea |
| Selective serotonin reuptake inhibitors (SSRIs) | These selectively block the reabsorption of serotonin by presynaptic transporter molecules, allowing more serotonin to stay in the synapse and improve communication between nerve cells involved in mood control. | Agitation, shakiness and anxiety, nausea, reduced appetite |
This variety allows treatments to be tailored to individual needs, though side effects must be carefully managed.
Psychological treatments for mood disorders
Psychological treatments address the cognitive and behavioural aspects of mood disorders, helping individuals reframe negative thought patterns. These therapies emphasise active participation and skill-building to manage symptoms long-term.
Beck's cognitive restructuring
Cognitive restructuring, developed by Aaron Beck, is a form of cognitive therapy that targets irrational beliefs contributing to depression. Irrational beliefs are distorted thoughts that exaggerate negative aspects of oneself, the world, or the future, often leading to emotional distress.
Core process:
- Therapists guide clients to identify these irrational beliefs, challenge them with evidence, and replace them with more balanced, rational perspectives.
- This helps individuals become less dependent on dysfunctional thinking and more objective in their attributions (explanations for events).
Techniques used:
- Socratic questioning - Therapists use guided questions to encourage clients to examine the validity of their thoughts.
- Psychoeducation - Clients learn about the link between thoughts, emotions, and behaviours.
- Homework - Practical tasks, such as journaling thoughts, reinforce new thinking patterns outside sessions.
Sessions usually last 50 minutes, with clients attending between five and twenty sessions. This approach builds resilience by teaching clients to manage their own thought processes.
Ellis's rational emotive behaviour therapy (REBT)
Rational emotive behaviour therapy (REBT), created by Albert Ellis, focuses on how interpretations of events, rather than the events themselves, drive emotional responses. It aims to replace self-defeating thoughts with healthier ones to reduce negative emotions and behaviours.
Key principles:
- Therapy emphasises present-focused solutions over dwelling on past events.
- Clients and therapists collaborate to dispute irrational beliefs, such as "musturbation" (rigid demands like "I must be perfect"), which lead to emotional turmoil.
Process:
- Identify self-defeating thoughts and their emotional consequences.
- Challenge these through logical, empirical, and pragmatic disputing (e.g., questioning if the belief is realistic or helpful).
- Develop acceptance of oneself, others, and life circumstances, embracing both positive and negative aspects.
REBT promotes personal responsibility and quick, practical changes in thinking. Clients learn to respond more adaptively to situations, fostering emotional stability without relying on external validation.
Strengths and weaknesses of treatments
Evaluating treatments involves weighing their effectiveness, practicality, and limitations.
| Approach | Strengths | Weaknesses |
|---|---|---|
| Biological | - Supporting evidence: A meta-analysis by Cipriani et al. (2018) reviewed 522 double-blind trials and found all 21 antidepressant drugs tested were more effective than placebos in reducing symptoms. - Practical advantages: These treatments are often cost-effective and require minimal time commitment compared to therapy sessions, making them accessible for many. | - Side effects: Many drugs cause debilitating effects, leading to low compliance; the most effective ones often have the poorest adherence rates. - Limited real-world impact: While statistically superior to placebos, the differences may not translate to substantial improvements in daily functioning. |
| Psychological | - High remission rates: In a study by Fava et al. (1998), 75% of participants receiving combined drug and cognitive therapy were symptom-free after two years, compared to only 25% on drugs alone. - Fewer side effects: These therapies avoid physical side effects, potentially improving long-term adherence. | - Non-compliance issues: Some individuals lack the organisation or motivation to complete homework tasks consistently. - Accessibility barriers: Requires trained therapists, which can be expensive or geographically limited, excluding many potential users. |
Supporting research
Cipriani et al. (2018):
- Method - Meta-analysis of 522 randomised, double-blind controlled trials comparing antidepressants to placebos.
- Results - All drugs showed greater efficacy than placebos in alleviating depressive symptoms.
- Evaluation - Provides robust evidence but highlights the need to consider individual responses and side effects.
Fava et al. (1998):
- Method - Longitudinal study comparing outcomes of drug treatment alone versus drugs plus cognitive therapy over two years.
- Results - Combined treatment led to a 75% remission rate, far higher than the 25% for drugs only.
- Evaluation - Demonstrates the added value of psychological input, though results may vary based on participant motivation.
These evaluations highlight that a combined approach often yields the best results.
Issues and debates in treatment approaches
Psychological treatments raise broader questions about the nature of human behaviour and societal influences. Two key debates are particularly relevant.
Individual versus situational explanations
Both biological and psychological treatments focus on changing aspects of the individual – that is, their biochemistry or their beliefs.
This sidelines the role of situational factors. Tackling sources of stress in society (e.g. poverty and discrimination) could also improve wellbeing without the need for treatment.
Determinism versus free will
Determinism suggests that behaviour is shaped by uncontrollable factors, such as irrational beliefs dictating emotional responses. In contrast, free will posits that individuals can actively choose their thoughts and actions.
Therapies like cognitive restructuring and REBT support free will by empowering clients to wilfully challenge and control negative thoughts, rather than being passively influenced by them. This perspective encourages personal agency in managing mood disorders.